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Buse JB, Vilsbll T, Thurman J et al (2014) Contribution of liraglutide in the fixed-ratio combination of insulin degludec and liraglutide (IDegLira)

In patients with T2D combined with arteriosclerotic cardiovascular disease (ASCVD) or very high cardiovascular risk, GLP-1 RAs have been recommended as one of the preferred combined medications

While this mechanism is intentional, it can become pathological in some patients

Behavioral strategies include self-monitoring of food intake and weight, stimulus control, problem-solving, and cognitive restructuring

There is no established research on long-term, uninterrupted human use, so cycling is the prudent approach